Nicotinamide Riboside vs. Nicotinic Acid

Attribute	Nicotinamide Riboside	Nicotinic Acid
Chemical Structure	Nicotinamide riboside is a pyridine-nucleoside form of vitamin B3.	Nicotinic acid is a form of vitamin B3 that is also known as niacin.
Function	Used as a precursor to nicotinamide adenine dinucleotide (NAD+).	Used in the treatment of high cholesterol and triglyceride levels.
Solubility	Water-soluble.	Water-soluble.
Side Effects	Generally well-tolerated, but may cause mild gastrointestinal symptoms.	May cause flushing, itching, and liver problems at high doses.

Introduction

Nicotinamide Riboside and Nicotinic Acid are two forms of vitamin B3, also known as niacin. Both compounds play important roles in the body's energy production and metabolism. While they are similar in some ways, there are also key differences between the two that are worth exploring.

Chemical Structure

Nicotinamide Riboside, also known as NR, is a form of vitamin B3 that is found in trace amounts in foods like milk and beer. It is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme that is involved in various cellular processes. Nicotinamide Riboside is converted into NAD+ through a series of enzymatic reactions in the body.

Nicotinic Acid, also known as niacin or vitamin B3, is another form of vitamin B3 that is found in foods like meat, fish, and nuts. It is also a precursor to NAD+ and is converted into NAD+ through a different pathway than Nicotinamide Riboside. Nicotinic Acid is often used as a dietary supplement to treat niacin deficiency and lower cholesterol levels.

Benefits

Nicotinamide Riboside has been studied for its potential anti-aging effects and its ability to improve mitochondrial function. Some research suggests that Nicotinamide Riboside supplementation may help increase NAD+ levels in the body, which could have a positive impact on cellular health and energy production. Additionally, Nicotinamide Riboside may help protect against age-related cognitive decline and improve exercise performance.

Nicotinic Acid is known for its ability to lower cholesterol levels and improve heart health. It is often used as a treatment for high cholesterol and triglyceride levels, as it can help reduce LDL cholesterol and increase HDL cholesterol. Nicotinic Acid may also help improve blood circulation and reduce the risk of cardiovascular disease.

Side Effects

Nicotinamide Riboside is generally considered safe and well-tolerated when taken at recommended doses. However, some people may experience mild side effects such as nausea, fatigue, or gastrointestinal discomfort. It is always important to consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions.

Nicotinic Acid can cause more pronounced side effects, especially at higher doses. Common side effects of Nicotinic Acid supplementation include flushing, itching, and liver toxicity. In some cases, Nicotinic Acid can also cause stomach ulcers, low blood pressure, and irregular heartbeat. It is important to follow dosing guidelines and monitor for any adverse reactions when taking Nicotinic Acid.

Availability

Nicotinamide Riboside is available as a dietary supplement in the form of capsules or powders. It can be purchased online or in health food stores. Nicotinamide Riboside supplements are often marketed for their anti-aging and energy-boosting properties, and may be more expensive than other forms of vitamin B3.

Nicotinic Acid is also available as a dietary supplement, typically in the form of tablets or capsules. It is widely used to lower cholesterol levels and improve heart health. Nicotinic Acid supplements can be found in pharmacies and grocery stores, and are generally more affordable than Nicotinamide Riboside supplements.

Conclusion

While Nicotinamide Riboside and Nicotinic Acid are both forms of vitamin B3 that play important roles in the body, they have distinct differences in terms of chemical structure, benefits, side effects, and availability. Nicotinamide Riboside may be more beneficial for those looking to improve mitochondrial function and combat aging, while Nicotinic Acid is better suited for individuals with high cholesterol levels or cardiovascular risk factors. It is important to consult with a healthcare provider before starting any new supplement regimen to determine the best option for your individual needs.