Invitrogen vs. Polyplus-Transfection

What's the Difference?

Invitrogen and Polyplus-Transfection are both well-known companies in the field of life sciences and biotechnology. Invitrogen, a subsidiary of Thermo Fisher Scientific, offers a wide range of products and services including reagents, kits, and instruments for various applications such as molecular biology, cell culture, and protein expression. On the other hand, Polyplus-Transfection specializes in the development and manufacturing of transfection reagents, which are essential tools for introducing nucleic acids into cells. While Invitrogen provides a broader range of products, Polyplus-Transfection focuses specifically on transfection reagents, offering a more specialized and targeted approach. Both companies are trusted by researchers worldwide and are known for their high-quality products and innovative solutions.


Product RangeWide range of products for molecular biology researchSpecializes in transfection reagents and related products
Company SizeLarge multinational companyMedium-sized company
Years in BusinessFounded in 1987Founded in 1998
Customer Support24/7 customer support availableCustomer support available during business hours
Research FocusOffers a wide range of research tools and technologiesSpecializes in transfection and nucleic acid delivery
Quality ControlStringent quality control measures in placeAdheres to strict quality control standards
Product InnovationContinuously develops new products and technologiesFocuses on innovative transfection solutions

Further Detail


When it comes to transfection reagents, researchers have a wide range of options to choose from. Two popular choices in the market are Invitrogen and Polyplus-Transfection. Both companies offer a variety of transfection reagents that are widely used in laboratories worldwide. In this article, we will compare the attributes of Invitrogen and Polyplus-Transfection, focusing on their product range, transfection efficiency, ease of use, customer support, and pricing.

Product Range

Invitrogen offers a comprehensive range of transfection reagents, including lipofection reagents, electroporation reagents, and viral transduction enhancers. Their lipofection reagents, such as Lipofectamine 3000 and Lipofectamine RNAiMAX, are widely used for DNA and RNA transfection, respectively. On the other hand, Polyplus-Transfection specializes in the development of innovative transfection reagents, with a focus on polymer-based solutions. Their flagship product, JetPRIME, is a versatile reagent suitable for a wide range of nucleic acid delivery applications. Polyplus-Transfection also offers other transfection reagents, such as jetMESSENGER and jetCRISPR, which are specifically designed for mRNA and CRISPR/Cas9 applications, respectively.

Transfection Efficiency

Transfection efficiency is a critical factor to consider when choosing a transfection reagent. Invitrogen's lipofection reagents have been widely used for many years and have a proven track record of high transfection efficiency in various cell types. Lipofectamine 3000, in particular, is known for its high efficiency in delivering DNA into a wide range of mammalian cells. Polyplus-Transfection's JetPRIME, on the other hand, offers comparable transfection efficiency to lipofection reagents. It has been optimized to deliver nucleic acids with high efficiency and low cytotoxicity, making it suitable for both research and therapeutic applications.

Ease of Use

Both Invitrogen and Polyplus-Transfection strive to provide transfection reagents that are easy to use. Invitrogen's lipofection reagents come with detailed protocols and optimized transfection conditions for various cell types, making it easier for researchers to achieve consistent results. They also offer transfection optimization kits that allow users to fine-tune their transfection conditions for maximum efficiency. Polyplus-Transfection's JetPRIME, on the other hand, is designed to be user-friendly, with a simple protocol that can be easily adapted to different cell types. The reagent is provided as a ready-to-use solution, eliminating the need for complex preparation steps.

Customer Support

Both Invitrogen and Polyplus-Transfection prioritize customer support to ensure researchers have a positive experience with their products. Invitrogen offers extensive technical support through their website, including FAQs, troubleshooting guides, and user forums where researchers can seek advice from fellow users. They also have a dedicated customer support team that can be contacted via email or phone for personalized assistance. Polyplus-Transfection also provides comprehensive technical support, including detailed protocols, application notes, and a knowledge base on their website. They offer direct support through their customer service team, ensuring that researchers can get prompt answers to their queries.


Pricing is an important consideration for researchers, especially those working with limited budgets. Invitrogen's transfection reagents are known to be relatively expensive compared to other brands in the market. However, the company justifies the higher price with the quality and performance of their products. Polyplus-Transfection, on the other hand, offers competitive pricing for their transfection reagents, making them an attractive option for researchers looking for cost-effective solutions without compromising on performance. It is worth noting that pricing may vary depending on the specific product and the region in which it is purchased.


Both Invitrogen and Polyplus-Transfection offer a range of transfection reagents that cater to the diverse needs of researchers. Invitrogen's lipofection reagents have a long-standing reputation for high transfection efficiency, while Polyplus-Transfection's polymer-based solutions provide comparable performance with added ease of use. Both companies prioritize customer support, ensuring researchers have access to technical assistance when needed. Pricing is a factor to consider, with Invitrogen generally being more expensive, but Polyplus-Transfection offering cost-effective alternatives. Ultimately, the choice between Invitrogen and Polyplus-Transfection will depend on the specific requirements of the research project and the budget available.

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