Hydroxyquinoline vs. Quinine
What's the Difference?
Hydroxyquinoline and Quinine are both chemical compounds with distinct properties and applications. Hydroxyquinoline, also known as 8-hydroxyquinoline, is a versatile compound commonly used as a chelating agent in various industries, including pharmaceuticals, cosmetics, and agriculture. It exhibits antimicrobial properties and is often employed as an ingredient in antiseptic creams and ointments. On the other hand, Quinine is a natural alkaloid derived from the bark of the cinchona tree. It is primarily known for its antimalarial properties and has been used for centuries to treat malaria. Quinine is also used in the production of tonic water, giving it its characteristic bitter taste. While both compounds have different applications, they share the commonality of being utilized in the medical field for their therapeutic properties.
Comparison
Attribute | Hydroxyquinoline | Quinine |
---|---|---|
Chemical Formula | C9H7NO | C20H24N2O2 |
Molecular Weight | 145.16 g/mol | 324.42 g/mol |
Structure | ![]() | ![]() |
Solubility | Soluble in organic solvents | Slightly soluble in water |
Uses | Antiseptic, disinfectant, pharmaceutical intermediate | Antimalarial, antipyretic, analgesic |
Derived From | Quinoline | Cinchona tree bark |
Further Detail
Introduction
Hydroxyquinoline and quinine are two chemical compounds that have distinct attributes and applications. While both compounds have been studied extensively for their medicinal properties, they differ in terms of their chemical structures, sources, uses, and potential side effects. In this article, we will explore the characteristics of hydroxyquinoline and quinine, highlighting their similarities and differences.
Chemical Structures
Hydroxyquinoline, also known as 8-hydroxyquinoline, is an organic compound with the molecular formula C9H7NO. It consists of a quinoline ring with a hydroxyl group attached to the eighth carbon atom. Quinine, on the other hand, is an alkaloid compound with the molecular formula C20H24N2O2. It features a complex structure composed of a quinoline ring fused with a quinuclidine ring system.
While both compounds contain a quinoline ring, the presence of additional functional groups and ring systems in quinine gives it a more intricate structure compared to hydroxyquinoline.
Sources
Hydroxyquinoline can be synthesized in the laboratory through various chemical reactions. It is commonly produced by the oxidation of 8-hydroxyquinoline-5-sulfonic acid or by the Skraup synthesis method. On the other hand, quinine is a natural compound that is primarily extracted from the bark of the cinchona tree, a plant native to South America.
The extraction of quinine from cinchona bark involves a complex process that includes grinding the bark, soaking it in a solvent, and subsequent purification steps. Due to its natural origin, quinine has been used for centuries in traditional medicine for its antimalarial properties.
Uses
Hydroxyquinoline has a wide range of applications in various industries. It is commonly used as a chelating agent in the production of rubber, textiles, and plastics. Its ability to form stable complexes with metal ions makes it useful in metal extraction and purification processes. Hydroxyquinoline is also employed as an intermediate in the synthesis of pharmaceuticals and dyes.
Quinine, on the other hand, is primarily known for its antimalarial properties. It has been used for centuries as a treatment for malaria, a mosquito-borne infectious disease. Quinine works by interfering with the growth and reproduction of the malaria parasite within the human body. Additionally, quinine has also been used to treat leg cramps and has found applications in the production of tonic water, which is a popular mixer for alcoholic beverages.
Potential Side Effects
While hydroxyquinoline is generally considered safe for use in industrial applications, it can have adverse effects when used in high concentrations or in certain formulations. Prolonged exposure to hydroxyquinoline may cause skin irritation, eye damage, or respiratory issues. It is important to handle this compound with proper safety precautions.
Quinine, when used as a medication, can also have side effects. Common side effects include nausea, vomiting, headache, and dizziness. In rare cases, quinine can cause more severe reactions such as allergic reactions, low blood sugar levels, or even cardiac arrhythmias. Due to these potential side effects, the use of quinine as an antimalarial drug is now limited to specific cases and under medical supervision.
Conclusion
In conclusion, hydroxyquinoline and quinine are two distinct compounds with different chemical structures, sources, uses, and potential side effects. Hydroxyquinoline is a synthetic compound commonly used in various industries, while quinine is a natural alkaloid primarily extracted from the cinchona tree and known for its antimalarial properties. Both compounds have their own unique applications and considerations for safe use. Understanding their attributes can help in utilizing their benefits effectively while minimizing any potential risks.
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