Crigler-Najjar vs. Gilbert's Syndrome

What's the Difference?

Crigler-Najjar syndrome and Gilbert's syndrome are both rare genetic disorders that affect the liver's ability to process bilirubin, a waste product of red blood cells. However, Crigler-Najjar syndrome is much more severe, causing dangerously high levels of bilirubin in the blood that can lead to neurological damage if left untreated. In contrast, Gilbert's syndrome is a milder condition that typically causes mild jaundice and fatigue, but does not usually require treatment. Both conditions are inherited in an autosomal recessive manner, but Crigler-Najjar syndrome is caused by mutations in the UGT1A1 gene, while Gilbert's syndrome is caused by mutations in the UGT1A1 gene regulatory region.



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