Cannabis vs. Mescaline

What's the Difference?

Cannabis and Mescaline are both psychoactive substances that can alter perception and mood. However, they differ in their effects and origins. Cannabis is a plant that contains the psychoactive compound THC, which produces a relaxed and euphoric high. Mescaline, on the other hand, is a naturally occurring psychedelic found in certain cacti, such as peyote. It induces hallucinations, altered thinking, and a sense of connection to the world. While both substances have been used for spiritual and recreational purposes, mescaline is typically considered to be more intense and profound in its effects compared to cannabis.


Photo by Matthew Brodeur on Unsplash
Plant TypeHerbaceousCactus
Active CompoundTHC, CBDMescaline
Legal StatusVaries by countryIllegal in most countries
EffectsRelaxation, euphoria, increased appetiteHallucinations, altered perception of time and space
Medical UsesPain relief, nausea, PTSDNone approved
Photo by Pretty Drugthings on Unsplash

Further Detail


When it comes to psychoactive substances, cannabis and mescaline are two popular choices that have been used for centuries for their mind-altering effects. While both substances can produce hallucinations and altered states of consciousness, they differ in their chemical composition, effects on the body and mind, and legal status. In this article, we will explore the attributes of cannabis and mescaline and compare their similarities and differences.

Chemical Composition

Cannabis, also known as marijuana, is derived from the Cannabis sativa plant and contains over 100 different cannabinoids, with the most well-known being tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the psychoactive compound responsible for the "high" associated with cannabis use, while CBD is non-psychoactive and has potential therapeutic benefits. On the other hand, mescaline is a naturally occurring psychedelic alkaloid found in several species of cacti, most notably the peyote cactus. Mescaline acts as a serotonin receptor agonist, producing hallucinogenic effects similar to LSD and psilocybin.

Effects on the Body

When consumed, cannabis can produce a range of effects on the body, including relaxation, euphoria, increased appetite, and altered perception of time. Some users may experience dry mouth, red eyes, and impaired coordination. Long-term cannabis use has been associated with memory and cognitive impairments, as well as respiratory issues from smoking. In contrast, mescaline can cause physical effects such as increased heart rate, dilated pupils, and elevated body temperature. Users may also experience nausea, vomiting, and muscle contractions. Unlike cannabis, mescaline is not typically associated with long-term physical health risks.

Effects on the Mind

Both cannabis and mescaline have profound effects on the mind, altering perception, mood, and cognition. Cannabis is known for its relaxing and euphoric effects, often leading to feelings of happiness, creativity, and introspection. Some users may experience anxiety, paranoia, or hallucinations, especially with high doses or potent strains. Mescaline, on the other hand, is a powerful hallucinogen that can induce intense visual and auditory distortions, as well as profound spiritual experiences. Users may report feelings of unity with nature, enhanced empathy, and a sense of interconnectedness with the universe.

Legal Status

The legal status of cannabis and mescaline varies widely around the world. In many countries, cannabis is illegal for recreational use but may be permitted for medical purposes or decriminalized for personal use. In recent years, several countries and states have legalized cannabis for recreational use, leading to a growing industry of cannabis products and dispensaries. Mescaline, on the other hand, is classified as a Schedule I controlled substance in the United States, meaning it is illegal to possess, distribute, or use without a license. In some countries, such as Mexico, the traditional use of peyote in religious ceremonies is protected under law.


In conclusion, cannabis and mescaline are two psychoactive substances with distinct attributes and effects on the body and mind. While cannabis is known for its relaxing and euphoric effects, mescaline is a powerful hallucinogen that can induce profound spiritual experiences. Both substances have potential therapeutic benefits and risks, depending on individual factors such as dosage, frequency of use, and set and setting. It is important for users to educate themselves about the effects and risks of cannabis and mescaline before consuming these substances and to use them responsibly and mindfully.

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