Adsorption Chromatography vs. Partition Chromatography

What's the Difference?

Adsorption chromatography and partition chromatography are two common techniques used in chromatography. In adsorption chromatography, the stationary phase is a solid material, such as silica gel or alumina, which adsorbs the analyte molecules based on their affinity for the stationary phase. On the other hand, partition chromatography uses a liquid stationary phase, typically coated on a solid support, where the analyte molecules partition between the stationary and mobile phases based on their solubility. While both techniques separate analytes based on their interactions with the stationary phase, adsorption chromatography is more suitable for polar compounds, while partition chromatography is better for nonpolar compounds. Additionally, adsorption chromatography typically requires a stronger eluent to desorb the analytes, while partition chromatography can be eluted with a less polar solvent.

Comparison

Further Detail

Comparisons may contain inaccurate information about people, places, or facts. Please report any issues.