Aceclofenac vs. Diclofenac

What's the Difference?

Aceclofenac and Diclofenac are both nonsteroidal anti-inflammatory drugs (NSAIDs) commonly used to relieve pain and reduce inflammation. However, there are some differences between the two. Aceclofenac is a derivative of Diclofenac and is considered to have a more favorable safety profile. It is known to cause fewer gastrointestinal side effects, such as stomach ulcers and bleeding, compared to Diclofenac. Additionally, Aceclofenac is believed to have a longer duration of action, providing prolonged pain relief. However, Diclofenac is available in various formulations, including oral tablets, topical gels, and injections, making it more versatile in terms of administration. Ultimately, the choice between Aceclofenac and Diclofenac depends on the individual's specific needs and medical history.


Chemical FormulaC16H13Cl2NO4C14H11Cl2NO2
Brand NamesHifenac, Acebel-P, Acenac, etc.Voltaren, Cataflam, Diclon, etc.
Therapeutic ClassNonsteroidal Anti-inflammatory Drug (NSAID)Nonsteroidal Anti-inflammatory Drug (NSAID)
IndicationsPain, inflammation, osteoarthritis, rheumatoid arthritisPain, inflammation, osteoarthritis, rheumatoid arthritis
Mode of ActionInhibits COX-2 enzymeInhibits COX-2 enzyme
Side EffectsStomach pain, nausea, headacheStomach pain, nausea, headache
ContraindicationsPeptic ulcer, severe liver or kidney diseasePeptic ulcer, severe liver or kidney disease

Further Detail


When it comes to managing pain and inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs) play a crucial role. Two commonly prescribed NSAIDs are Aceclofenac and Diclofenac. While both medications belong to the same class, they have distinct attributes that set them apart. In this article, we will delve into the similarities and differences between Aceclofenac and Diclofenac, exploring their mechanisms of action, uses, side effects, and more.

Mechanism of Action

Aceclofenac and Diclofenac share a similar mechanism of action, inhibiting the production of prostaglandins, which are responsible for pain and inflammation. However, Aceclofenac is a prodrug, meaning it is converted into its active form, diclofenac, in the body. This conversion allows Aceclofenac to exert its therapeutic effects.


Aceclofenac and Diclofenac are both used to relieve pain and inflammation associated with various conditions, such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and musculoskeletal disorders. Additionally, they can be prescribed for postoperative pain, dental pain, and gynecological conditions like dysmenorrhea.

Formulations and Dosage

Aceclofenac is available in tablet form, typically in strengths of 100 mg or 200 mg. It is usually taken twice daily, with or after meals. On the other hand, Diclofenac is available in various formulations, including tablets, capsules, gels, and injections. The dosage and frequency of Diclofenac administration depend on the specific formulation and the condition being treated.

Side Effects

Both Aceclofenac and Diclofenac can cause similar side effects, although their incidence and severity may vary. Common side effects include gastrointestinal disturbances such as abdominal pain, indigestion, nausea, and diarrhea. In some cases, these medications can lead to more serious adverse effects like gastric ulcers, bleeding, and liver or kidney problems. It is important to use these drugs under medical supervision and report any unusual symptoms promptly.

Cardiovascular Risks

Recent studies have raised concerns about the cardiovascular risks associated with long-term use of NSAIDs, including Aceclofenac and Diclofenac. Prolonged use of these medications may increase the risk of heart attack, stroke, and other cardiovascular events. Patients with pre-existing cardiovascular conditions or those at high risk should exercise caution and discuss the potential risks with their healthcare provider.

Drug Interactions

Both Aceclofenac and Diclofenac can interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. It is important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting either of these drugs. Certain medications, such as anticoagulants, diuretics, and certain antidepressants, may interact with Aceclofenac or Diclofenac, necessitating dose adjustments or alternative treatment options.

Precautions and Contraindications

While Aceclofenac and Diclofenac are generally well-tolerated, there are certain precautions and contraindications to consider. Both medications should be avoided in patients with a history of hypersensitivity to NSAIDs or those who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Additionally, caution should be exercised in patients with a history of gastrointestinal bleeding, peptic ulcers, liver or kidney impairment, and heart failure.

Comparing Efficacy

When it comes to comparing the efficacy of Aceclofenac and Diclofenac, it is important to note that individual responses may vary. Some studies suggest that Aceclofenac may have a faster onset of action and provide more rapid pain relief compared to Diclofenac. However, more research is needed to establish definitive differences in efficacy between the two medications.

Cost and Availability

In terms of cost and availability, Diclofenac tends to be more widely available and may be available in generic forms, making it a more cost-effective option for some patients. Aceclofenac, on the other hand, may be more expensive and less readily available in certain regions.


Aceclofenac and Diclofenac are both valuable NSAIDs used for managing pain and inflammation. While they share similarities in their mechanism of action and uses, there are notable differences in terms of formulations, dosage, side effects, and availability. It is essential to consult with a healthcare professional to determine the most suitable option based on individual needs, medical history, and potential drug interactions. By understanding the attributes of Aceclofenac and Diclofenac, patients can make informed decisions regarding their pain management and overall well-being.

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